Splet06. feb. 2024 · TPX2 promotes MT stability and stimulates MT nucleation [5–8]; interestingly, recent cryo-EM data shed new light on TPX2 interaction with MTs, providing structural basis to the complexity of TPX2 e ects on MTs [9]. TPX2 has also been described as an essential factor in augmin-mediated branching MT nucleation using Xenopus egg … SpletAbstract. For more than 15 years, TPX2 has been studied as a factor critical for mitosis and spindle assembly. These functions of TPX2 are attributed to its Ran-regulated …
TPX2 as a Novel Prognostic Indicator and Promising Therapeutic …
Splet14. sep. 2024 · GROUND・オカムラ／ユナイテッドアローズの物流戦略紹介 ... 所在地：千葉県印西市松崎台2-4-3 Amazon TPX2 開始時期：10月13日 ... SpletTPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules. Ran-GTP activates TPX2 for the chromatin … tousipa
Structural insight into TPX2-stimulated microtubule assembly
Splet27. jan. 2024 · TPX2 is the target protein for Xenopus plus end-directed kinesin-like protein (Xklp2) and contains the TPX domain. It has previously been considered a micro-tubulin interacting protein and... SpletTPX2（Targeting Protein for Xklp2）是真核细胞纺锤体组装核心调控蛋白，缺失会抑制纺锤体的组装和形成。 脊椎动物的TPX2中包含一个特征结构域，而在植物中包含两个。 植物TPX2在有丝分裂间期主要定位于细胞核内，而在分裂期、核膜崩溃之前就运输到纺锤体预定形成处、起始纺锤体的形成。 分裂后期TPX2主要定位于纺锤体微管上和成膜体，在分裂 … TPX2 has been shown in several biochemical assays to behave as a microtubule-associated protein (MAP) and co-localize with spindle microtubules during M-phase. It plays a role in microtubule nucleation and is regulated by importin proteins. TPX2 serves as a complement, depleting importin α affinity in order to … Prikaži več Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase Prikaži več TPX2 has been reported to have two NLS-containing domains that mediate its localization to microtubules; one in the amino-terminal domain, and the other in the carboxy-terminal domain. In addition to an NLS, the carboxy-terminal domain of TPX2 consists of Prikaži več When bound to microtubules, TPX2 recruits a plus-end directed motor protein, Xlp2, a protein that is required in early mitosis and localizes to spindle poles, to microtubule minus … Prikaži več When the cell is in interphase, because of its ability to bind to importin α and β, TPX2 has been found localized in the nucleus. This has been … Prikaži več TPX2 recruits and activates Aurora A kinase by utilizing its short 43 amino acid long amino-terminal sequence to bind the catalytic domain of Aurora A, locking the kinase into its … Prikaži več When four-fold TPX2 over the endogenous level was injected into a blastomere with a two-cell embryo, cleavage arrest was induced. This arrest has been attributed to the amino acids … Prikaži več Monitoring TPX2 gene mRNA expression during cell cycle progression in synchronized HeLa cells revealed that TPX2 expression is high in G2/M phase, decreases dramatically upon G1 phase entry, increases upon entry into S phase, and peaks again at … Prikaži več poverty application